England winger Monye, who has not played for his club since the second match of the season due to injury, takes the place of Gonzalo Camacho.
Camacho himself is now sidelined after picking up an injury during Quins' Amlin Challenge Cup triumph away at Connacht.
Ceri Jones is also ruled out, so boss Conor O'Shea, who will come up against Irish for the first time since he left the club five years ago, is also forced into changes in the pack.
Joe Marler comes into a front row that also contains Joe Gray and James Johnston, while in the second row George Robson returns to partner Ollie Kohn.
Will Skinner is drafted in alongside captain Chris Robshaw and Nick Easter in the back row in place of Tom Guest, who has been given something of a boost with the news that his ankle problem is not as serious as first thought.
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